Table 1.
The list of Aedes aegypti genes with m6A sites, which were differentially expressed in response to DENV infection.
| Name | Gene description | Fold change | p-value | DENV-infected (RPKM) | Mock (RPKM) | m6A Peak |
|---|---|---|---|---|---|---|
| AAEL026586 | Unspecified product | 179.5 | 3.57E–03 | 0.090 | 0.000 | Peaks 1170, 1171, 1172, 1173, 1174, 1175 |
| AAEL025779 | SUMO-conjugating enzyme UBC9-B | 10.01 | 5.28E–03 | 0.100 | 0.010 | Peak 5676 |
| AAEL001548 | Glucosyl/glucuronosyl transferases | 2.97 | 3.88E–03 | 0.180 | 0.070 | Peak 75 |
| AAEL002737 | Cytochrome c oxidase, subunit VIIC, putative | 2.92 | 1.84E–07 | 2.450 | 1.090 | Peak 419 |
| AAEL010801 | Cytochrome b-c1 complex subunit 6 | 2.52 | 4.63E–10 | 3.780 | 1.960 | Peak 2602 |
| AAEL020290 | 60S ribosomal protein L39 | 2.46 | 9.30E–09 | 21.180 | 11.470 | Peak 3632 |
| AAEL013320 | Translocon-associated protein, delta subunit | 2.21 | 2.07E–06 | 2.830 | 1.760 | Peak 2056 |
| AAEL005414 | ER membrane protein complex subunit 6 | 2.19 | 1.49E–07 | 3.780 | 2.260 | Peak 5123 |
| AAEL012629 | Deoxyuridine 5′-triphosphate nucleotidohydrolase | 2.11 | 3.23E–04 | 1.270 | 0.780 | Peak 1207 |
| AAEL012010 | Conserved hypothetical protein | 2.1 | 2.62E–06 | 1.770 | 1.100 | Peak 3237 |
| AAEL026055 | Unspecified product | −2 | 0.04 | 0.070 | 0.180 | Peaks 893, 894, 895 |
| AAEL007801 | Exonuclease | −2.03 | 9.21E–05 | 0.530 | 1.440 | Peak 2577 |
| AAEL019660 | Zwei Ig domain protein zig-8-like isoform X2 | −2.07 | 1.15E–03 | 0.070 | 0.170 | Peaks 2648, 2649, 2650 |
| AAEL014064 | Glutaredoxin, putative | −2.1 | 2.62E–06 | 12.950 | 35.310 | Peak 1640 |
| AAEL028092 | Fibroblast growth factor receptor homologue 1 | −2.27 | 2.35E–03 | 0.060 | 0.180 | Peak 5095 |
| AAEL020452 | Titin-like protein | −2.44 | 4.00E–02 | 0.005 | 0.020 | Peaks 249, 250 |
| AAEL019573 | Hemicentin-1 | −3.02 | 8.11E–03 | 0.020 | 0.070 | Peak 2187 |
| AAEL008811 | NADH dehydrogenase 3 | −3.36 | 2.77E–07 | 2.320 | 10.690 | Peak 5723 |
| AAEL004711 | Testis specific leucine rich repeat protein | −3.64 | 8.32E–03 | 0.040 | 0.190 | Peak 1555 |
| AAEL005072 | MRAS2, putative | −3.84 | 0.02 | 0.020 | 0.080 | Peak 5390 |
| AAEL006650 | Potassium channel beta | −3.9 | 6.93E–03 | 0.009 | 0.050 | Peak 2792 |
| AAEL009825 | 60S ribosomal protein L13a | −4.83 | 4.00E–02 | 0.030 | 0.210 | Peak 5624 |
| AAEL021404 | Unspecified product | −5.02 | 1.00E–02 | 0.010 | 0.090 | Peak 5605 |
| AAEL014303 | Neuroligin | −12.64 | 3.78E–03 | 0.002 | 0.030 | Peak 936 |
| AAEL002518 | Glutamate receptor, ionotropic kainate 1, 2, 3 | −37.12 | 0.05 | 0.000 | 0.010 | Peak 4351 |
| AAEL020891 | Vacuolar protein sorting-associated protein 13B | −359.05 | 5.54E–04 | 0.000 | 0.080 | Peak 5667 |
Only four genes (in italic) showed differential m6A and gene expression upon DENV infection.