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. 2022 Jun 20;12:10333. doi: 10.1038/s41598-022-13569-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Haplotype analysis of the candidate ATG7 allele (p.R659*). (a) Extended haplotype of the 45 Mb deleted region of chromosome 3p in individual III:8. The blocks indicate the original fragmented haplotypes, and their color denotes their subsequent assignment to haplotypes covering many Megabases. The candidate ATG7 allele exists in haplotype 1 (blue), which was the non-deleted haplotype in the tumor of this individual. (b) Germline haplotype analysis of siblings for the ATG7 genomic region. The haplotype segregation across all eight siblings in generation III was determined for the 0.8 Mb genomic region surrounding the ATG7 allele (red dot). The candidate ATG7 allele exists in haplotype 1 (blue).