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. 2022 Jun 20;12:10387. doi: 10.1038/s41598-022-14320-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RyR2 knockout increases the number of discrete intranuclear JP2 signal spots in 2 months matured hiPSC-CMs. (A) Confocal images showing the DAPI-stained central nuclear imaging sections of WT versus RyR2 knockout hiPSC-CMs. Whereas one JP2 M epitope-labeled signal spot was apparent inside the WT hiPSC-CM nucleus, the number of signal spots was increased in RyR2 knockout hiPSC-CMs. Scale bar, 5 μm. (B) Dot plot comparing the intranuclear area-normalized number of JP2 signal spots between WT and RyR2 KO hiPSC-CMs. Data are represented as mean ± SD; n = 25 cells per group. Student’s t-test; **p < 0.01.