Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 21;8:58. doi: 10.1038/s41421-022-00402-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Schematic representation of the experimental procedure. Patients with cancer-related lymphedema (n = 5; the CASE group) and healthy donors (n = 4; the CTRL group) were recruited in this study. Liposuction specimens from the thighs were collected during surgery. scRNA-seq was performed separately for each individual. b Unbiased clustering of 70,209 cells revealed 21 cellular clusters. The number in parentheses represents the cell count. c Hierarchical clustering of the clusters based on the mean expression of the 2000 most variable genes. d Expression of the established marker genes for each lineage in each cluster. e Representative molecular signatures for each cell cluster. The area of the circles indicates the proportion of cells expressing the gene, and the color intensity reflects the expression intensity. ASC, adipose-derived stromal/stem/progenitor cell; cDC, conventional dendritic cell; EDO, endothelial cell; MAC, macrophage; NK, natural killer cell; NKT, natural killer T cell; prolif.NKT, proliferative nature killer T cell; pDC, plasmacytoid dendritic cell.