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. 2022 Jun 21;8:58. doi: 10.1038/s41421-022-00402-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Visualization of the cellular density reveals dramatic changes in the proportions of multiple cell lineages in CASE versus CTRL. An equal number of cells (n = 28,935) were randomly sampled for each group. b Significantly expanded or contracted cell lineages. c Significantly expanded or contracted cellular clusters. d The distribution of cells for each cluster in each individual. In b and c, a permutation-based statistical test (differential proportion analysis) was performed. Data are represented as means ± SE. *Bonferroni-corrected P value < 0.05; **Bonferroni-corrected P value < 0.01. CASE, cancer-associated lymphedema; CTRL, healthy control.