Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 21;8:58. doi: 10.1038/s41421-022-00402-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a GSEA reveals upregulated or downregulated pathways of ASCs in CASE versus CTRL. An FDR q value < 0.05 was considered to be statistically significant. b Comparative analysis of the gene regulatory networks of ASCs between the CASE (lower panel) and CTRL (upper panel) groups reveals dysregulated genes in ASCs. The node size reflects the degree centrality. The representative genes dysregulated in CASE ranked by delta degree are labeled in red. c Network view of the functional enrichment for the dysregulated genes shown in b. The small dots denote genes and large nodes represent Gene Ontology terms. The node size represents the number of genes associated with the Gene Ontology term. Adjusted P value < 0.05. d Delta degree centrality (upper panel) and average expression across cells in CASE and CTRL (lower panel). CASE, cancer-associated lymphedema; CTRL, healthy control.