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. 2022 Jun 21;8:58. doi: 10.1038/s41421-022-00402-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Intercellular communication networks in the adipose tissues from patients with lymphedema (CASE; right panel) and healthy people (CTRL; left panel). The total number of communications is shown for each cell lineage. The line color indicates that the ligands are broadcast by the cell lineage in the same color. The line thickness is proportional to the number of broadcast ligands. b Heatmap shows the number of communications between any two lineages in the CASE (right panel) and CTRL (left panel) groups. c The ligand–receptor pairs showing significant changes in specificity between any one of the non-ASC lineages and ASCs in CASE versus CTRL. ASCs express receptors and receive ligand signals from other lineages. The dot size reflects the p value of the permutation tests for lineage specificity. The dot color denotes the mean of the average ligand–receptor expression in the interacting lineages. d The ligand–receptor pairs showing significant changes in specificity between ASCs and any one of the non-ASC lineages in CASE versus CTRL. ASCs express ligands and broadcast ligand signals for other lineages. ASC, adipose-derived stromal/stem/progenitor cell; BC, B cell; CASE, cancer-associated lymphedema; CTRL, healthy control; DC, dendritic cell; EDO, endothelial cell; MAC, macrophage; NK, natural killer cell; NKT, natural killer T cell; TC, T cell.