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. 2022 Jun 20;13:3535. doi: 10.1038/s41467-022-31124-7

Fig. 1. Variable expression of EphB4 and ephrinB2 is found on HNSCC tumor cells and within the TME across different tumor models.

Fig. 1

Representative HNSCC tumor sections stained with anti-ephrinB2 and CD31 antibodies (a) or anti-ephrinB2 and EpCAM antibodies (b) confirm the variable expression of ephrinB2 in both epithelial and CD31-expressing vascular endothelial cells. c EphB4 is also evident in CD31+ endothelial cells and on d EpCAM+ epithelial cells in different tumor models. e Dual immunofluorescence staining performed on Moc2 tumors show co-localization of EphB4 on alpha-SMA expressing fibroblasts. f Multiplex staining by VECTRA analysis validates the immunofluorescence data in Moc2 tumor. A representative composite image along with dual-color staining is shown. Total magnification: x200.