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. 2022 Apr 30;12(6):1313–1323. doi: 10.1007/s13555-022-00733-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Mindera dermal biomarker patch. A Patches are approximately 2 cm in diameter with an array of 100 square pyramidal microneedles in the center of the patch arranged in a 5 × 5 mm² square. Each pyramidal microneedle is 750 µm in length and 200 µm × 200 µm at the base. B Representation of modified microneedles with ssDNA probes bound to the surface; C application of dermal biomarker patch to the skin using spring-loaded applicator; D dermal biomarker patch applied to skin for sample collection