Biomarkers have become a preferred method for disease detection and patient monitoring. Furthermore, the development of robust biomarker sets has brought the promise of precision medicine to the treatment of a number of diseases.

Multiple biomarker sets related to skin diseases have been identified, but access to skin biomarkers has largely been limited to invasive skin biopsies.

We hypothesized that chemically modified microprojections could provide a minimally invasive method to efficiently capture mRNA from the skin.

Using this platform, we have successfully and reproducibly extracted the transcriptome both from the skin of healthy individuals as well as skin lesions of psoriasis patients.

The dermal biomarker patch platform described herein could enable access to previously inaccessible datasets and enable novel study into the skin transcriptome.

Application of this platform could lead to high-precision diagnostics as well as the realization of precision medicine in dermatology.