Table 2.

Comparison of melanin index, erythema index, mMASI score, and skin roughness over six time points using generalized estimating equation. b, regression coefficient

	Melanin index		Erythema index		Skin roughness		mMASI
	b	p-Value	b	p-Value	b	p-Value	b	p-Value
Group
Control	−4.917	0.452	−2.450	0.624	−0.158	0.763	0.013	0.784
Treatment	–	–	–	–	–	–	–	–
Time point
Baseline	–	–	–	–	–	–	–	–
2 weeks	−14.195	0.245	−7.228	0.447	−0.840	0.006*	−1.206	< 0.001*
1 month	−24.187	0.010*	−15.760	0.086	−0.814	0.006*	−1.356	< 0.001*
2 months	−36.350	< 0.001*	−26.126	0.009*	−0.942	0.002*	−1.292	< 0.001*
3 months	−38.231	< 0.001*	−12.808	0.176	−0.881	0.002*	−1.142	< 0.001*
6 months	−63.902	< 0.001*	−13.335	0.300	−1.136	< 0.001*	−1.287	< 0.001*

b regression coefficient, mMASI Modified Melasma Area and Severity Index