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. 2022 May 16;81(7):925–936. doi: 10.1136/annrheumdis-2021-221957

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Better response in disease activity on prednisolone compared with placebo. Left: long-term change in disease activity estimated in primary model, model with time-treatment interactions, and as observed (unadjusted), with numbers of patients with available data. Right: short-term response at 3 months in the per-protocol population, according to EULAR and ACR criteria, and for minimal disease activity state (DAS28 <2.60) and Boolean remission. The time–treatment interaction terms for 3, 18 and 24 months were statistically significant. The grey area depicts the one-sided 95% confidence bound for the difference between groups at each time point. Error bars depict one half of the two-sided 95% CI for the group means. ACR, American College of Rheumatology; DAS28, Disease Activity Score 28 joints; EULAR, European League Against Rheumatism.