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. 2022 Jun 7;25(7):104551. doi: 10.1016/j.isci.2022.104551

Figure 2.

Figure 2

Evolution of gene expression changes from field effects through HGIN to UC in bladder cancer developing along the luminal track in map 24

(A) Hierarchical clustering of mucosal and tumor samples using the top 60 most downregulated and overexpressed genes showing monotonic expression changes in samples corresponding to NU/LGIN through HGIN to UC, HGIN and UC, and UC only.

(B) Whole-organ expression map of chromosome 10 showing a chromosomal diagram and the expression pattern for genes in individual cystectomy samples classified as NU/LGIN, HGIN, and UC.

(C) Expression pattern for downregulated and overexpressed genes with monotonic changes involving NU/LGIN, HGIN, and UC in chromosome 10.

(D) Three-dimensional (3D) pattern of downregulated and overexpressed genes in mucosal and tumor samples as it relates to the whole-organ histologic map of a cystectomy sample filtered as in C.