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. 2022 Jun 7;12:904327. doi: 10.3389/fonc.2022.904327

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Copyright © 2022 Voisin, Nicole, Gratio, Chassac, Mansour, Rebours, Couvelard and Couvineau

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA-seq and Western blot analysis of gemcitabine- and Nab-paclitaxel-chemoresistant tumors treated or not by OxA. (A) Heatmap of mRNA expression in gemcitabine- and Nab-paclitaxel-chemoresistant tumors treated or not by OxA. (B) Diagram of functional enrichment analysis of mRNA expression in gemcitabine- and Nab-paclitaxel-chemoresistant tumors treated or not by OxA. (C) NrF2, Bcl2, p-elF2α, PolQ, FoxM1, SHP-2, cleaved-PARP, ATF3, and ATF4 factor expression in gemcitabine- and Nab-paclitaxel-chemoresistant tumors treated or not by OxA. (D) Semi-quantitative analysis of cleaved-PARP and ATF3 expression in gemcitabine- and Nab-paclitaxel-chemoresistant tumors treated or not by OxA, determined by Western blot.