Figure 4.

Representative histologic micrographs of Spitz nevi. (A) Low power overview of a compound Spitz nevus, which show symmetry and circumscription. The lesion is characterized by spindled and epithelioid cell morphology (2x). Inset: Higher power view of the same Spitz nevus with junctional nest “hanging” from the epidermis and prominent Kamino bodies (arrowhead) (20x). (B) Low power view of pigmented spindle cell nevus of Reed with the characteristic heavy pigmentation (10x). Inset: Higher power view of the same lesion demonstrating spindle cell morphology and heavy pigmentation (20x). (C) Intradermal desmoplastic Spitz nevus, showing effacement of rete ridge and an exclusively intradermal, amelanotic melanocytic proliferation. Inset: High power view showing predominantly epithelioid melanocytes distributed between thick collagen bundles.