Table 2.
Clinical characteristics of subjects carrying variants in the genes associated with MO
| Gene | Position (GRCh37) | SNP ID | Change in DNA | Change in protein | Case control ratio | Age, years | Gender | BMI, kg/m2 | % body fat | Diabetes | History of surgery |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ADCY3 | 25,059,790 | rs115329263 | c.1658C>T | p.A553V | 4:1 | 28 50 57 46 30 |
F M F M M |
40.8 40.3 37.1 38.3 23.8 |
44 36.1 47.7 36.6 21.5 |
No Yes No No No |
No No No No Gastric restriction |
|
| |||||||||||
| ADCY3 | 25,141,368 | rs143034828 | c.489C>G | p.H163Q | 1:0 | 50 | M | 36.5 | 36.9 | No | No |
|
| |||||||||||
| MC3R | 54,824,819 | rs1481948431 | c.920G>A | p.Arg307His 1:0 | 60 | F | 39 | 47.3 | No | No | |
|
| |||||||||||
| MC4R | 58,039,098 | rs1555691402 | c.485C>T | p.T1621 | 3:00 | 39 33 57 |
F F F |
39.3 42.8 39 |
47.5 51.2 47.1 |
No No Yes |
No No No |
|
| |||||||||||
| MRAP2 | 84,765,081 | rs760845706 | c.44C>T | p.S15L | 1:00 | 39 | M | 40.6 | 40.1 | No | No |
|
| |||||||||||
| MRAP2 | 84,799,133 | rs1054400375 | c.551T>C | p.I184T | 1:00 | 35 | M | 40.8 | 36.2 | No | No |
|
| |||||||||||
| MRAP2 | 84,798,925 | rs368589399 | c.343C>G | p.L115V | 1:00 | 39 | M | 23.9 | 16.8 | Yes | Gastric restriction |
|
| |||||||||||
| PCSK1 * | 95,761,591 | rs567748971 | c.329G>A | p.R110H | 1:00 | 33 | F | 38.3 | 47.4 | Yes | No |
|
| |||||||||||
| PCSK1 * | 95,735,682 | rs1026383684 | c.1405G>A | p.V4691 | 2:00 | ||||||
|
| |||||||||||
| PCSK1 | 95,728,961 | rs748072514 | c.2006G>T | p.R669L | 1:00 | 32 | M | 41.1 | 36.9 | No | No |
|
| |||||||||||
| POMC | 25,384,596 | rs28932470 | c.158A>G | p.D53G | 1:00 | 39 | M | 37.2 | 33.4 | No | No |
*
Compound heterozygous for two PCSK1 variants.