Table 3.
Bodyweight and survival time of P. berghei-infected mice treated with A. africana crude extract in the 4-day suppression test.
| Treatment | Weight (g) |
|||
|---|---|---|---|---|
| Dose (mg/kg) | W0 | W4 | Survival time | |
| A. africana | 200 | 25.42 ± 2.06 | 25.44 ± 1.75 | 10.40 ± 1.40b3,c2 |
| 400 | 27.19 ± 0.55 | 26.36 ± 1.86 | 14.60 ± 1.28b2,a1 | |
| 600 | 27.79 ± 1.29 | 27.64 ± 1.52 | 15.60 ± 1.80b2,a1 | |
| 1000 | 25.07 ± 1.27 | 22.22 ± 1.72 | 19.00 ± 2.30b1,a1 | |
| 1500 | 20.37 ± 3.17 | 22.12 ± 4.68 | 24.00 ± 2.53a1 | |
| N. Saline (ml) | 10 | 24.92 ± 2.72 | 23.08 ± 3.38 | 6.60 ± 0.74b3 |
| Art/Lum | 1.14 | 28.94 ± 2.14 | 33.67 ± 1.53a1 | 30.00 ± 0.00 |
The results are expressed as mean ± SEM; n = 5; acompared to normal saline treated group, bcompared to Artemeter-Lumefantrine, ccompared to 1500 mg/kg group, 1p < 0.05, 2p < 0.001, 3p < 0.0001. W0 = before extract treatment on day 0, W4 = post-treatment on day 4, W = weight.