. Author manuscript; available in PMC: 2023 Apr 14.

Published in final edited form as: Br J Nutr. 2021 Jun 30;127(7):1000–1009. doi: 10.1017/S0007114521001732

Table 2.

Spearman partial correlation coefficients of oestrone, oestradiol, SHBG, testosterone, free oestradiol, free testosterone, and oestradiol/testosterone with body shape and BMI across the lifespan in men (HPFS), postmenopausal (NHS+ NHS II) and premenopausal women (NHS+ NHS II)

Men
	Body shape (age 5)	Body shape (age 10)	BMI (age 21)	BMI (age 50)	BMI (age at blood draw)	BMI change (age 21- blood draw)
Oestrone (pg/ml)	0.009^d	0.006^d	0.15^b	0.21^b	0.14^b	0.02^d
Oestradiol (pg/ml)	0.03^d	0.03^d	0.10^b	0.17^b	0.14^b	0.06^c
SHBG (nmol/l)	0.05^c	0.03^d	−0.02^d	−0.23^b	−0.31^b	−0.32^b
Testosterone (ng/dl)	0.06^c	0.02^d	−0.03^d	−0.21^b	−0.30^b	−0.30^b
Free oestradiol (pg/ml)	0.02^d	0.03^d	0.11^b	0.29^b	0.29^b	0.21^b
Free testosterone (ng/dl)	0.02^d	−0.02^d	−0.04^c	−0.05^d	−0.11^b	−0.10^b
Oestradiol/testosterone	−0.004^d	0.03^d	0.11^b	0.32^b	0.38^b	0.31^b
Postmenopausal women
	Body shape (age 5)	Body shape (age 10)	BMI (age 18)	BMI (age 50)	BMI (age at blood draw)	BMI change (age 18- blood draw)
Oestrone (pg/ml)	0.02^d	0.04^d	0.07^b	0.24^b	0.26^b	0.22^b
Oestradiol (pg/ml)	0.02^d	0.04^c	0.10^b	0.39^b	0.44^b	0.39^b
SHBG (nmol/l)	0.004^d	−0.02^d	−0.06^b	−0.35^b	−0.39^b	−0.37^b
Testosterone (ng/dl)	0.005^d	−0.007^d	0.007^d	−0.02^d	−0.02^d	−0.02^d
Free oestradiol (pg/ml)	−0.004^d	0.02^d	0.07^b	0.47^b	0.54^b	0.50^b
Free testosterone (ng/dl)	−0.007^d	0.001^d	0.04^b	0.25^b	0.28^b	0.27^b
Oestradiol/testosterone	0.04^d	0.06^b	0.09^b	0.39^b	0.43^b	0.38^b
Premenopausal women
	Body shape (age 5)	Body shape (age 10)	BMI (age 18)	BMI (age 40)	BMI (age at blood draw)	BMI change (age 18- blood draw)
Oestrone (pg/ml)	0.001^d	0.004^d	−0.007^d	0.05^c	0.06^c	0.09^b
Oestradiol (pg/ml)	−0.04^d	−0.05^b	−0.10^b	−0.13^b	−0.13^b	−0.09^b
SHBG (nmol/l)	−0.02^d	−0.06^b	−0.15^b	−0.45^b	−0.48^b	−0.47^b
Testosterone (ng/dl)	−0.01^d	−0.01^d	0.02^d	−0.003^d	0.001^d	−0.01^d
Free oestradiol (pg/ml)	−0.02^d	−0.01^d	−0.02^d	0.09^b	0.11^b	0.14^b
Free testosterone (ng/dl)	0.02^d	0.06^b	0.14^b	0.35^b	0.37^b	0.35^b
Oestradiol/testosterone	−0.03^d	−0.04^d	−0.10^b	−0.12^b	−0.12^b	−0.07^b

Partial correlation with adjustment for age at blood draw. SHBG, Sex-hormone Binding Globulin; BMI, Body Mass Index; HPFS, Health Professional Follow-Up Study; NHS, Nurse’ Health Study; NHS II, Nurse’ Health Study II.

P-values:

P < 0.001;

P < 0.05;

P ≥ 0.05.