TABLE II.
Benralizumab allowed some subjects to reduce medical therapies for EGID and liberalize dietary restrictions
| No. | BL Tx | Diet at BL | Week 48 Tx | Diet at week 48 |
|---|---|---|---|---|
| 6* | P 10 mg daily, HU 1 g daily | Unrestricted | P 15 mg | Unrestricted |
| 7 | Budesonide 9 mg FV 440 twice a day | Avoids: chicken and beef plus FA foods | Budesonide 6 mg, FV 440 twice a day | No attempt to reintroduce foods; eats more freely |
| 11 | Budesonide 3 mg | Unrestricted | None | Unrestricted |
| 13 | None | Avoids: carrots, peas, apple, mango, banana, watermelon, kiwi, strawberry, turkey, direct egg, corn, wheat, oats | None | Reintroduced most foods Avoids: wheat and mango |
| 14 | FV 220 2p twice a day | Consumes only shrimp, potato, fruit (apple, pear, lemon, banana), vegetables (broccoli, lettuce) | FV 220 2p twice a day | Reintroduced fish, poultry, tomato, carrots. Unable to tolerate avocado and shrimp |
| 15* | None | Unrestricted, but planned mealtimes to avoid symptoms | None | Eats unrestricted diet freely |
| 16 | FV 220 2p twice a day | Avoids: corn, rice, most meats, shrimp, shellfish, and pure egg | FV 220 2p twice a day | No attempts to reintroduce foods |
Budesonide, Budesonide slurry; P, prednisone; FA, food allergy; FV, swallowed fluticasone; HU, hydroxyurea; Tx, treatment.
Subjects with lymphoid HES and GI involvement. Remaining subjects were HES single-organ overlap (EGID). Subject #6 relapsed at week 32 and taken off benralizumab.