Fig. 1.

Treatment and sample collection timelines for the 2014 and 2017 protocols. For all studies, 27 blood samples were collected at baseline and during the 12-hour period after start of dermal administration. Only four of these samples were analyzed in 2014 to evaluate analytical detection and for method development (0.5, 1, 6 and 12-hours). All samples from the 2017 protocol were analyzed to capture both the early and late-stage kinetics.