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. Author manuscript; available in PMC: 2022 Jun 21.
Published in final edited form as: Environ Int. 2020 Aug 13;144:106031. doi: 10.1016/j.envint.2020.106031

Table 3.

Plausibility check of the fraction dermally absorbed (Fabs), as obtained by three different approaches, in terms of serum clearance of unconjugated BPA.

Approach Fabs (%) Dose D (nmol) AUC (nM × h) CL (L/h)
Recovery of total BPA in urine 1 34,141 7.51 45
Serum AUCs of total BPA after oral and dermal administration 2.2 95.5
Mass-balance considerations based on recovery of unabsorbed BPA 12–29 545–1318

The absolute dermal dose (D, nmol) derives from the per-body-weight dose of 100 μg/kg BW multiplied by a body weight of 80 kg and divided by the molecular mass of 234.32 g/mol for d6-BPA. The assumed body weight is representative for the six subjects from which the estimate for the mean serum AUC of 7.51 nM × h for unconjugated BPA was obtained. The serum clearance for unconjugated BPA (CL) was calculated as: CL = Fabs/100% × D/AUC.