Table 5.
Positive associations between rCMglc and semantic fluency in aMCI (amnestic MCI) group (N= 179)
| Index | Brain Regions | BA | Coordinates (mm) |
Extent Voxels (N) | T value | Z score | p (uncorrected) | ||
|---|---|---|---|---|---|---|---|---|---|
| X | Y | Z | |||||||
| Total Score | L middle frontal gyrus | 10 | −23 | 56 | 21 | 1079 | 4.07 | 3.97 | < 0.001 |
| R superior frontal gyrus | 10 | 26 | 52 | 24 | 592 | 4.03 | 3.94 | < 0.001 | |
| R anterior insula | 13 | 38 | 10 | −8 | 1722 | 3.90 | 3.81 | < 0.001 | |
| L anterior cingulate | 32 | −1 | 40 | 9 | 1078 | 3.74 | 3.67 | < 0.001 | |
| L caudate | – | −5 | 15 | −2 | 1103 | 3.55 | 3.48 | < 0.001 | |
| L thalamus | – | −7 | −7 | 11 | 402 | 3.54 | 3.47 | < 0.001 | |
| R middle temporal gyrus | 21 | 65 | −19 | −6 | 262 | 3.41 | 3.35 | < 0.001 | |
| R inferior temporal gyrus | 20 | 59 | −32 | −21 | 612 | 3.40 | 3.34 | < 0.001 | |
| L inferior temporal gyrus | 20 | −48 | −5 | −34 | 151 | 3.34 | 3.29 | < 0.001 | |
| Switching | R superior temporal gyrus | 38 | 41 | 3 | −12 | 1392 | 3.96 | 3.87 | < 0.001 |
| R inferior temporal gyrus | 20 | 45 | −16 | −27 | 106 | 3.33 | 3.28 | < 0.001 | |
| L superior frontal gyrus | 10 | −19 | 57 | 14 | 76 | 3.28 | 3.22 | < 0.001 | |
| R superior frontal gyrus | 10 | 26 | 54 | 22 | 24 | 3.22 | 3.17 | < 0.001 | |
| Cluster switching | L thalamus | – | −11 | −8 | 13 | 673 | 3.73 | 3.66 | < 0.001 |
| L caudate | – | −10 | 18 | 0 | 244 | 3.45 | 3.38 | < 0.001 | |
| R Thalamus | – | 3 | −7 | −3 | 112 | 3.36 | 3.30 | < 0.001 | |
| R caudate | – | 10 | 16 | 0 | 193 | 3.34 | 3.28 | < 0.001 | |
| R inferior parietal lobule | 40 | 62 | −28 | 38 | 149 | 3.33 | 3.27 | < 0.001 | |
SPM12 analysis of covariance output for all patients with age, education, and sex as covariates; BA, Brodmann areas; L, left hemisphere; R, right hemisphere; PCC, posterior cingulate cortex.