Table 1.

Functional enrichment among thermotolerance loci

GO term	n observed:nexpected	Adjusted P	Name	Total n
Cellular component
GO: 0000775	5:1	0.0366	Chromosome, centromeric region	75
GO: 0000778	4:0	0.0256	Kinetochore	40
Molecular function
GO: 0000149	3:0	0.0701	SNARE binding	28
GO: 0008081	2:0	0.0256	Phosphoric diester hydrolase activity	11
GO: 0004843	2:0	0.0998	Thiol-dependent deubiquitinase	24
Biological process
GO: 0007165	3:0	0.0923	Signal transduction	59
GO: 0001403	3:0	0.0923	Invasive growth in response to glucose limitation	42
GO: 0046580	2:0	0.0256	Negative regulation of Ras protein signal transduction	6
GO: 0001934	2:0	0.0256	Positive regulation of protein phosphorylation	5
GO: 0016042	2:0	0.0923	Lipid catabolic process	26
GO: 0034087	2:0	0.0923	Establishment of mitotic sister chromatid cohesion	16

Each row with numerical data reports a GO term enriched for RH-seq hit genes. n_observed, the number of genes from among top hits from thermotolerance RH-seq that were annotated with the term. n_expected, the number of genes annotated with the term in the same number of randomly chosen genes from the genome, as a median across samples. Adjusted P, resampling-based significance of the enrichment after Benjamini–Hochberg correction.