FIGURE 2.

The effect of curcumin on clinical outcome and pathological form of α-synuclein in skin nerves. P-syn samples and adnexa rates increased in untreated patients differently from supplemented patients showing a decrease of p-syn deposits although the difference from baseline is not significant. Untreated patients show a worsening of all clinical scales despite the increase of L-dopa dosage. Patients supplemented with curcumin showed an increase only of MDS-UPDRS and H&Y scores. Although less than the untreated group, COMPASS-31 and NMSS decreased over the follow-up with an opposite trend compared to the untreated group. *Asterisk indicates significant changes from baseline.