FIGURE 3.

Phosphorylated α-synuclein (p-syn) deposits in skin nerves in a supplemented PD patient during the follow-up period. Confocal microscope (×400) study of p-syn in skin nerves of a patient with PD at baseline (A) and after the follow-up period (B). Abundant nerve fibers are found around a skin arteriole identified by PGP 9.5. Some of these fibers presented abnormal neuritic inclusions of misfolded α-synuclein depicted by staining phosphorylation at Ser 129 (p-syn, arrows). The number of fibers expressing p-syn was higher at baseline (A) than after the follow-up (B). The number of deposits (arrows) around a skin arteriole was decreased after 1 year of supplementation of curcumin (B). Higher magnification images of nerve fibers showing misfolded α-synuclein aggregates are in boxes. Scale bar: 50 µm.