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. 2021 Dec 13;12(2):jkab427. doi: 10.1093/g3journal/jkab427

Table 2.

Mutations associated with fungicide resistance in pan-azole-resistant A. fumigatus

Isolate Source cyp51A—azolesa cytB—QoIb benA—MBCc
A1163 Clinic WT WT WT
eAF222 Environment, 2018 USA TR46/Y121F/T289A G143A F219Y
eAF233 Environment, 2018 USA TR46/Y121F/T289A G143A F219Y
eAF234 Environment, 2018 USA TR46/Y121F/T289A G143A F219Y
eAF513 Environment, 2018 USA TR46/Y121F/T289A G143A F219Y
08-12-12-13 Clinic, 2003 Netherlands TR34/L98H/ WT F219Y
08-31-08-91 Clinic, 2004 Netherlands TR34/L98H WT F219Y
08-36-03-25 Clinic, 2005 Netherlands TR34/L98H WT F219Y
10-01-02-27 Clinic, 2010 Netherlands TR34/L98H G143A F219Y
Afu 942/09 Clinic, 2009 India TR34/L98H G143A F219Y
Afu 1042/09 Clinic, 2009 India TR34/L98H G143A F219Y
Afu 124/E11 Environment, 2011 India TR34/L98H G143A F219Y
Afu 166/E11 Environment, 2011 India TR34/L98H G143A F219Y
Afu 218/E11 Environment, 2011 India TR34/L98H G143A F219Y
Afu 257/E11 Environment, 2011 India TR34/L98H G143A F219Y
Afu 343/P11 Clinic, 2011 India TR34/L98H G143A F219Y
Afu 591/12 Clinic, 2012 India TR34/L98H G143A F219Y
DI 15-96 Clinic, 2008 USA TR46/Y121F/T289A G143A F219Y
DI 15-102 Clinic, 2010 USA TR34/L98H WT F219Y
DI 15-106 Clinic, 2012 USA TR46/Y121F/T289A G143A F219Y
DI 15-116 Clinic, 2014 USA TR34/L98H WT F219Y
a

GenBank accession number EDP50065 from azole-sensitive isolate A1163 was used as wildtype for Cyp51A. Isolates 08-12-12-13 and 08-36-03-25 also carried S297T/F495I mutations for Cyp51A, but these have not been associated with azole resistance.

b

GenBank accession number YP_005353050 from azole-sensitive isolate A1163 was used as wildtype for CytB. All cyp51A TR mutants also carried V13I/I119V mutations for CytB, but these have not been associated with QoI resistance.

c

GenBank accession number EDP56324 from azole-sensitive isolate A1163 was used as wildtype for BenA.