Table 4.

Subgroup analysis by late-life physical activity intensity between amyloid positivity and AD-related neurodegeneration

Subgroup	Dependent variable	Independent variable	Beta	95% CI	p
Lower late-life PA group	AD-CM	Aβ positivity	−0.259	−0.127~−0.019	0.009
	AD-CT	Aβ positivity	−0.192	−0.153~−0.009	0.028
Higher late-life PA group	AD-CM	Aβ positivity	−0.170	−0.109~0.007	0.086
	AD-CT	Aβ positivity	−0.102	−0.086~0.020	0.219

Adjusted for age, sex, education, apolipoprotein E ε4, vascular risk score, cognitive activity score, and clinical diagnosis. Lower late-life PA group (n = 130) consisted of participants who performed median and below median values of late-life PA whereas higher late-life PA group (n = 130) consisted of the ones who performed above median value of PA. AD, Alzheimer’s disease; CI, confidence interval; PA, physical activity; AD-CM, Alzheimer’s disease signature region cerebral glucose metabolism; Aβ, amyloid-β; AD-CT, Alzheimer’s disease signature cortical thickness.