Table 3.
Descriptive table for harmonized parameters associated with serum phosphate across eGFR category by cohort
| eGFR Category (mL/min/1.73m2): | ≤20 | 21-30 | 31-40 | 41-50 | >50 | P-value | |
|---|---|---|---|---|---|---|---|
| # of subjects with serum phosphate | CRIC | 83 | 666 | 956 | 1029 | 1136 | NA |
| CKD-JAC | 778 | 688 | 647 | 409 | 110 | NA | |
| Serum phosphate, mg/dL* | CRIC | 4.7 ± 1.0 | 4.1 ± 1.0 | 3.8 ± 0.7 | 3.6 ± 0.6 | 3.5 ± 0.6 | <0.001 |
| CKD-JAC | 3.6 ± 0.6 | 3.3 ± 0.5 | 3.2 ± 0.5 | 3.1 ± 0.5 | 3.1 ± 0.5 | <0.001 | |
| PTH, pg/mL* | CRIC | 166 [101 - 234] | 101 [63 - 159] | 63 [41 - 99] | 48 [33 - 74] | 39 [29 - 56] | <0.001k |
| CKD-JAC | 208 [144 - 310] | 119 [87 - 164] | 91 [68 - 122] | 78 [57 - 105] | 70 [50 - 96] | <0.001k | |
| Intact FGF23, pg/mL* | CRIC | 123 [69 - 186] | 73 [58 - 121] | 60 [45 - 80] | 47 [38 - 62] | 42 [33 - 53] | <0.001k |
| CKD-JAC | 91 [60 - 147] | 60 [45 - 83] | 49 [38 - 67] | 40 [33 - 53] | 37 [31 - 50] | <0.001k | |
| 25OHD, ng/mL* | CRIC | 14.0 [10.2 - 23.7] | 20.7 [12.6 - 31.4] | 21.4 [13.5 - 31.7] | 22.6 [13.9 - 34.1] | 23.9 [14.7 - 33.4] | 0.001k |
| CKD-JAC | 12.6 [6.8 - 19.7] | 13.4 [7.6 - 21.6] | 14.6 [8.5 - 23.3] | 14.5 [8.2 - 23.4] | 16.0 [7.8 - 21.5] | <0.001k | |
| Phosphate Binders, N (%) | CRIC | 12 (14.5) | 71 (10.7) | 69 (7.2) | 48 (4.7) | 57 (5.0) | <0.001c |
| CKD-JAC | 62 (8.0) | 19 (2.8) | 10 (1.6) | 2 (0.5) | 1 (0.9) | <0.001c | |
| Active vitamin D, N (%) | CRIC | 7 (8.4) | 61 (9.2) | 34 (3.6) | 16 (1.6) | 4 (0.4) | <0.001c |
| CKD-JAC | 87 (11.2) | 63 (9.3) | 46 (7.2) | 28 (7.0) | 16 (15.0) | 0.010c | |
| Native vitamin D, N (%) | CRIC | 3 (3.6) | 69 (10.4) | 105 (11.0) | 96 (9.4) | 117 (10.4) | 0.250c |
| CKD-JAC | NA | NA | NA | NA | NA | NA | |
| Calcium intake by DHQ, mg/day | CRIC | 758 [494 - 961] | 605 [396 - 891] | 580 [407 - 810] | 610 [361 - 873] | 645 [449 - 887] | 0.009k |
| CKD-JAC | 274 [193 - 404] | 335 [234 - 442] | 362 [261 - 510] | 376 [292 - 514] | 338 [206 - 539] | <0.001k | |
| Phosphorus intake by DHQ, mg/day | CRIC | 1272 [864 - 1601] | 1005 [708 - 1398] | 1013 [700 - 1346] | 1070 [769 - 1450] | 1106 [804 - 1496] | <0.001k |
| CKD-JAC | 666 [487 - 880] | 726 [561 - 922] | 787 [619 - 1040] | 846 [677 - 1067] | 761 [586 - 1135] | <0.001k | |
| Carbonated beverage intake, N (%) <1 drink/week 1-6 drinks/week 1-3 drinks/day 4 drinks or more/day |
CRIC | 9 (22.0) 16 (39.0) 10 (24.4) 6(14.6) |
124 (25.3) 166 (33.6) 167 (34.0) 34 (6.9) |
178 (26.5) 235 (34.9) 219 (32.5) 41 (6.1) |
194 (24.6) 284 (36.0) 259 (32.9) 51 (6.5) |
272 (30.2) 300 (33.3) 270 (30.0) 59 (6.6) |
0.271c |
| CKD-JAC | 323 (62.0) 163 (31.3) 33 (6.3) 2 (0.4) |
302 (63.6) 132 (27.8) 34 (72) 7 (1.5) |
275 (62.5) 129 (29.3) 32 (7.3) 4 (0.9) |
161 (61.0) 85 (32.2) 17 (6.4) 1 (0.4) |
50 (65.8) 23 (30.3) 3 (4.0) 0 (0.0) |
0.753c | |
| uPhos/uCr, g/gCr | CRIC | 0.59 [0.44 - 0.71] | 0.58 [0.44 - 0.75] | 0.56 [0.43 - 0.73] | 0.56 [0.43 - 0.71] | 0.57 [0.44 - 0.73] | 0.759k |
| CKD-JAC | 0.42 [0.33 - 0.52] | 0.42 [0.31 - 0.53] | 0.40 [0.28 - 0.51] | 0.41 [0.30 - 0.56] | 0.37 [0.24 - 0.49] | 0.007k | |
Data are expressed as mean ± S.D. or median [interquartile range]. Superscripts “c” and “k” stand for χ2 test and Kruskal-Wallis test, respectively; ANOVA was performed unless otherwise noted. Abbreviations: NA, not available; eGFR, estimated glomerular filtration rate; Alb, serum albumin; PTH, parathyroid hormone; FGF23, fibroblast growth factor-23; 25OHD, 25-hydroxyvitamin D; DHQ, dietary health questionnaire; uPhos/uCr, urine phosphate-to-creatinine ratio.
*
Data were harmonized between CRIC and CKD-JAC.