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. Author manuscript; available in PMC: 2022 Jun 21.
Published in final edited form as: DNA Repair (Amst). 2020 Jul 10;94:102926. doi: 10.1016/j.dnarep.2020.102926

Table 3.

Non-Proteasomal Proteases for TOP-DPC.

Proteases Organisms TOP1-DPC TOP2-DPC Notes References
SPRTN Human Mouse Yes Yes In vitro and in vivo for TOP1-DPC (human, mouse) and TOP2-DPC (human) [128,129,132]
Wss1 Yeast Yes Unknown In-vitro and in-vivo evidence for TOP1-DPC after CPT treatment, in parallel with TDP1. [126]
GCNA/ACRC C. elegans, mouse, Drosophila melanogaster, human Unknown Yes Selective for germline and early embryo across species. (C. elegans, Drosophila melanogaster and mouse) [154,155]
Ddi1 Yeast Yes Unknown In vivo [146,156]
FAM111A Human Yes Unknown In vivo for TOP1-DPC [158]