Table 2.
Insulin resistance change in 30 active rheumatoid arthritis patients naïve to biologics by tofacitinib therapy
|
Group
|
Before
|
After
|
P
value1
|
| All (n = 30) | |||
| DAS28 | 6.291 ± 0.530 (5.16-7.37) | 3.101 ± 0.522 (2.08-4.21) | < 0.001 |
| Decrease in DAS28 | 3.194 ± 0.609 (1.94-4.36) | ||
| HOMA-IR | 2.639 ± 1.185 (1.07-5.89) | 1.947 ± 0.714 (0.98-4.19) | < 0.001 |
| QUICKI | 0.3353 ± 0.0222 (0.296-0.380) | 0.3492 ± 0.0183 (0.310-0.385) | < 0.001 |
| High IR (n = 18) | |||
| DAS28 | 6.499 ± 0.472 (5.56-7.37) | 3.006 ± 0.444 (2.52-4.21) | < 0.001 |
| Decrease in DAS28 | 3.499 ± 0.536 (2.36-4.36) | ||
| HOMA-IR | 3.331 ± 1.036 (2.04-5.89) | 2.292 ± 0.707 (1.21-4.19) | < 0.001 |
| QUICKI | 0.3207 ± 0.0135 (0.296-0.343) | 0.3397 ± 0.0154 (0.310-0.372) | < 0.001 |
| Low IR (n = 12) | |||
| DAS28 | 5.980 ± 0.470 (5.16-6.69) | 3.244 ± 0.614 (2.08-3.99) | < 0.001 |
| Decrease in DAS28 | 2.736 ± 0.389 (1.94-3.23) | ||
| HOMA-IR | 1.602 ± 0.294 (1.07-2.00) | 1.430 ± 0.293 (0.98-2.02) | 0.139 |
| QUICKI | 0.3573 ± 0.0117 (0.344-0.380) | 0.3634 ± 0.0122 (0.343-0.385) | 0.156 |
1
Before vs after TOF therapy.
HOMA-IR: Homeostatic model assessment-insulin resistance; QUICKI: Quantitative Insulin Sensitivity Check Index; DAS28: Disease Activity Score 28.