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. Author manuscript; available in PMC: 2023 Jun 9.
Published in final edited form as: Cell. 2022 Jun 9;185(12):2132–2147.e26. doi: 10.1016/j.cell.2022.04.016

Figure 1. Cryo-EM structure of human NEXT complex bound to RNA substrate 1.

Figure 1.

(A) NEXT subunits and their domain organization.

(B) Composite map of human NEXT homodimer generated from local 3D refinement.

(C) Model of human NEXT homodimer bound to RNA substrate 1 in two orientations. Each subunit is labeled and colored uniquely.

(D) Solvent-excluded surface representation of NEXT protomer A in two orientations with each domain labeled and colored as in (A). See also Figure S1-3 and Table S1.