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. 2022 Jun 20;19:162. doi: 10.1186/s12974-022-02525-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Comparison of L5-VRT and SNI-induced mechanical allodynia and expression of TNF-α and IL-6 in bilateral ACC. A Changes in bilateral mechanical paw withdrawal thresholds of SNI and L5-VRT operated rats. Significant differences are observed in threshold for ipsilateral paw in rats with SNI and bilateral paws in rats with L5-VRT on day 3, 5 and 7. n = 6 rats in each group. Statistical significance is determined by Dunn's multiple comparisons test (*p < 0.05; **p < 0.01; ***p < 0.001 versus PO-1d) or multiple t tests (#p < 0.05 versus contralateral side). B L5-VRT and SNI-induced expression of TNF-α and IL-6 proteins in bilateral ACC. Upper left, the tissue of Cg1 and Cg2 (red region) was used for western blotting. Sections were in the coronal plane, number in mm anterior to Bregma indicated in this and subsequent figures. Representative western blotting of TNF-α and IL-6 protein levels in bilateral ACC are shown on the upper right. The quantification results are shown below. Significant differences are observed on the contralateral side in the SNI group but on the bilateral side in the L5-VRT group 7d after nerve injury. *p < 0.05, **p < 0.01 versus sham group (one-way ANOVA)