Table 1.
Comparison of the baseline characteristics and pathological outcomes between the AYA and non-AYA groups
| Characteristics | AYA group (n = 73) | Non-AYA group (n = 170) | P value |
|---|---|---|---|
| Age (years) | 36.0 ± 4.4 | 62.0 ± 6.4 | < 0.01 |
| Sex, n (%) | |||
| Male | 56 (76.7%) | 140 (82.4%) | |
| Female | 17 (23.3%) | 30 (17.6) | NS |
| Etiology, n (%) | |||
| HBV | 60 (82.1%) | 141 (83.0%) | |
| Others | 13 (17.8%) | 29 (17.0%) | NS |
| BMI (kg/m2) | 22.1 ± 1.2 | 20.6 ± 0.9 | NS |
| AST (U/L) | 42 (23–119) | 50 (16–269) | NS |
| ALT (U/L) | 62 (22–167) | 54 (9–204) | NS |
| Albumin (g/dL) | 4.2 ± 0.4 | 4.0 ± 0.5 | NS |
| Total bilirubin (mg/dL) | 0.7 ± 0.4 | 0.7 ± 0.4 | NS |
| Platelet (× 103/mm3) | 199 (40–362) | 183 (66–393) | NS |
| INR | 1.1 ± 0.1 | 1.1 ± 0.1 | NS |
| AFP (ng/dL) | 5923 (2–59,403) | 3341 (1–59,779) | < 0.01 |
| PIVKA-II | 271 (10–500) | 238 (11–500) | NS |
| ICG R15 (%) | 8.5 (2.4–41.5) | 10.0 (3.7–48.6) | NS |
| Child-Pugh grade B, n (%) | 2 (3.0%) | 5 (2.9%) | NS |
| Family history of HCC or other cancers, n (%) | 15 (20.5%) | 20 (11.8%) | < 0.05 |
| Maximum tumor size > 5 cm | 42 (57.5%) | 76 (44.1) | < 0.05 |
| Multiple tumors | 6 (8.2%) | 15 (8.8%) | NS |
| Microvascular invasion | 64 (87.7%) | 121 (71.2%) | < 0.01 |
| Portal vein invasion | 24 (32.9%) | 33 (19.4%) | < 0.01 |
| Satellite nodules | 12 (16.4%) | 31 (18.2%) | NS |
| Edmondson grade | |||
| I + II | 36 (49.3%) | 151 (88.8%) | |
| III + IV | 37 (50.7%) | 19 (11.2%) | < 0.01 |
| Tumor capsule formation | 39 (53.4%) | 126 (74.1%) | < 0.01 |
| Hepatic capsule invasion | 8 (11.0%) | 9 (5.3%) | <0.01 |
| Microvascular tumor emboli | 47 (64.4%) | 119 (70.0%) | NS |
| TNM stage | |||
| I + II | 25 (34.2%) | 68 (40.4%) | |
| III + IV | 48 (65.8%) | 102 (60.0%) | NS |
| Resection margin < 1 cm | 36 (49.3%) | 77 (45.3%) | NS |
HCC hepatocellular carcinoma, NS not significant