Table 1.
Characteristics of the included studies
| First author (year) | Country | Time span | Case number (low/high) | Histological type | TNM | Antibody source | Counting method | Cutoff (positive) | Subcellular localization | Outcome | NOS score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Takanami (2003) | Japan | 1992–1996 | 71(29/42) | NSCLC | I-III | R&D | P | 10% | membrane and/or cytoplasm | NA | 6 |
| Spano (2004) | France | 1987–1999 | 61(44/17) | NSCLC | I | Abcam | S + P | scores = 6/9 | nucleus | OSa | 8 |
| Su (2005) | China | NA | 34 (17/17) | NSCLC | I-III | R&D | S | ≥ normal | membrane and/or cytoplasm | NA | 6 |
| Na (2008) | Germany | NA | 46 (24/22) | NSCLC | I-IV | Abcam | S | scores = 3 | cytoplasm/nucleus | NA | 6 |
| Song (2008) | Korea | 1995–1999 | 323 (275/48) | NSCLC | I-IV | Abcam | P | > 50% | cytoplasm and nucleus | OS/DFSa | 7 |
| Suzuki (2008) | Japan | 1995–2000 | 90(68/22) | NSCLC | I-IV | Santa Cruz | P | ≥ 10% | membrane and/or cytoplasm | OSa | 6 |
| Wagner (2009) | America | NA | 154(92/62) | NSCLC | I-IV | R&D | S | scores ≥ 2 | membrane/nucleus | DFS | 7 |
| Chen (2011) | China | 1998.1–2008.6 | 64(13/51) | NSCLC | I-IV | Abcam | S + P | scores ≥ 3 | membrane and/or cytoplasm | NA | 8 |
| Otsuka (2011) | Canada | 2003–2006 | 170(141/29) | NSCLC | IV | Abcam | AQUA | scores ≥ 3371 | cytomembrane | OSa | 8 |
| Wang (2011) | China | 2002–2004 | 208(91/117) | NSCLC | I-III | R&D | S + P | scores ≥ 2 | cytoplasm | OS | 8 |
| Zhou (2012) | China | 2002.6–2006.12 | 105(33/62) | NSCLC | III | Boao Sen | S + P | scores ≥ 4 | cytoplasm | NA | 6 |
| Al Zobair (2013) | China | NA | 125(63/62) | NSCLC | I-IV | Abcam | S + P | scores ≥ 2 | cytoplasm | OS | 8 |
| Li (2014) | China | 1999–2009 | 50(15/35) | SCLC | I-IV | R&D | S + P | scores > 2 | membrane and/or cytoplasm | OSa | 9 |
| Wang (2014) | China | 1998.1–2008.1 | 105(42/63) | NSCLC | I-IV | Abcam | S + P | scores ≥ 4 | NA | NA | 7 |
| Kaemmerer (2015) | Germany | 1998–2011 | 90(23/47) | BP-NEN | NA | UMB-2 | S + P | scores ≥ 5 | membrane | OSa | 8 |
| Li (2015) | China | 2003.6–2009.10 | 65(31/34) | SCLC | I-III | Abcam | S + P | scores ≥ 6 | cytoplasm | OSa | 6 |
NSCLC Non-small cell lung cancer, BP-NENS Bronchopulmonary neuroendocrine neoplasms, AC Adenocarcinoma, ASC Adenosquamous carcinoma, S Staining intensity, P Percentage of positively-stained cells, HR Hazard ratio
aextracted from the Kaplan–Meier survival curves, OS Overall survival, DFS Disease-free survival, DSS Disease specific survival, NOS Newcastle–Ottawa Scale, NA Not available