Table 4.
Subgroup analysis of the association between CXCR4 expression and clinicopathological indicators
| parameters | No. of studies | Cases | Pooled OR (95% CI) |
P | I2(%) | Effect model |
|---|---|---|---|---|---|---|
| Tumor stage | ||||||
| Geographical area | ||||||
| non-Asian | 2 | 200 | 1.32(0.65–2.68) | 0.438 | 0 | Fixed |
| Asian | 7 | 849 | 2.95(1.37–6.34) | 0.006 | 64.1 | Random |
| Subcellular localization | ||||||
| membrane and/or cytoplasm | 2 | 249 | 7.76(2.03–29.69) | 0.003 | 0 | Fixed |
| cytoplasm | 2 | 318 | 4.02(2.23–7.26) | < 0.001 | 0 | Fixed |
| membrane and nucleus | 2 | 294 | 1.28(0.68–2.40) | 0.446 | 0 | Fixed |
| Distant metastasis | ||||||
| Geographical area | ||||||
| non-Asian | 3 | 370 | 1.93(0.56–6.72) | 0.301 | 61.4 | Random |
| Asian | 4 | 552 | 5.33(1.68–16.94) | 0.005 | 81.2 | Random |
| Subcellular localization | ||||||
| membrane and/or cytoplasm | 2 | 234 | 1.78(0.37–8.56) | 0.056 | 72.7 | Random |
| cytoplasm and nucleus | 2 | 364 | 1.89(1.08–3.30) | 0.867 | 0 | Fixed |
| TNM stage | ||||||
| Subcellular localization | ||||||
| membrane and/or cytoplasm | 7 | 641 | 2.75(1.15–6.56) | 0.023 | 70.7 | Random |
| cytoplasm | 5 | 576 | 6.18(3.98–9.59) | 0 | 40.1 | Fixed |
| membrane and nucleus | 2 | 294 | 1.56(0.94–2.59) | 0.088 | 0 | Fixed |
OR Odds ratio