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. 2022 Jun 21;20:291. doi: 10.1186/s12951-022-01504-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — iPSCs-KCs-Exos accelerate deep second-degree burn wound healing in vivo. A Representative images of wounds treated with PBS or iPSCs-KCs-Exos on days 0, 3, 7, and 11 after burning and quantitative analysis of wound area in each group. n = 6 mice per group. B H&E staining of wounded skin sections treated with PBS or iPSCs-KCs-Exos on days 3, 7, and 11 after burning. Black arrows indicate the dermal border; green arrows indicate the epidermal margin. Scale bar, 400 μm. C Quantitative analysis of the re-epithelialization ratio of wounds in each group. D Quantitative analysis of the length of epithelial tongues of wounds in each group. E Immunohistochemistry staining for CD31 wounds and quantitative analysis of the numbers of stained capillaries in each group on days 11 after burning. Scale bar, 50 μm. F Masson’s trichrome staining of wounds in each group on days 7 and 11 after burning. Scale bar, 50 μm. *P < 0.05, **P < 0.01