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. 2022 Jun 21;20:295. doi: 10.1186/s12951-022-01497-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — P/LLL/AP2/rh nanoconjugates for BBB penetration. a Chemical composition of P/LLL/AP2/rh, optical imaging data showing nanoconjugate permeation of the cerebral cortex (A_1-3) and average nanoconjugate fluorescence in brain parenchyma (B_1-3). b Pharmacokinetics of nanoconjugate in serum (P/LLL/AP2/rh and P/LLL/rh) and brain tissue (optical imaging of the sagittal sinus blood vessel). c Vascular fluorescence intensity profile (right) for the sagittal sinus vessel as indicated with a yellow line (only 30 min drug accumulation shown in the left). d Time dependence of nanoconjugate fluorescence intensity in brain parenchyma. Reprinted from ref. [107], with permission from the American Chemical Society, Copyright 2019