Table 2.

Functional characteristics of the 30 CF children

Characteristics	With bronchial congestion			Without bronchial congestion			After versus before AD, all patients	After salbutamol versus before all patients	Between 2 groups (with and without) at baseline
	N = 10			N = 20
Lung function	Before AD	After AD	After salbutamol	Before AD	After AD	After salbutamol
VD, cm3	80 [71; 112]	90 [75; 104]	ND	76 [44; 121]	85 [55; 120]	ND	0.097		0.509
VD/height, cm2	0.53 [0.46; 0.70]	0.61 [0.55; 0.66]	ND	0.53 [0.37; 0.70]	0.60 [0.41; 0.75]	ND	0.098		0.660
Spirometry, patients, n		10	7		17	7
FEV1, L	ND	1.66 [1.14; 2.32]	1.87 [1.38; 2.42]	ND	2.01 [1.56; 2.59]	1.81 [0.97; 2.49]		0.007
FEV1, z-score	ND	− 2.49 [− 3.51; − 2.09]	− 2.30 [− 3.47; − 1.80]	ND	− 0.72 [− 2.41; 0.14]$	− 2.38 [− 3.89; − 2.25]
FVC, L	ND	2.33 [1.55; 3.31]	2.38 [1.89; 3.35]	ND	2.73 [1.97; 3.54]	2.51 [1.77; 3.47]		0.195
FVC, z-score	ND	− 1.53 [− 2.66; − 0.35]	− 1.18 [− 2.34; − 1.11]	ND	− 0.16 [− 1.52; 0.48]	− 1.54 [− 2.03; − 0.35]
FEV1/FVC	ND	0.75 [0.70; 0.77]	0.78 [0.72; 0.79]	ND	0.81 [0.70; 0.83]	0.69 [0.59; 0.76]		0.064
FEV1/FVC, z-score	ND	− 2.08 [− 2.53; − 1.44]	− 1.84 [− 2.31; − 1.68]	ND	− 1.04 [− 2.31; − 0.84]	− 2.39 [− 3.48; − 1.49]
IOS, patients, n	10	10	10	20	20	20
Fres, Hz	20.97 [14.34; 23.93]	18.82 [13.88; 26.12]	11.9 [11.2; 25.3]	19.21 [13.76; 25.13]	18.99 [14.74; 22.95]	18.3 [14.5; 25.5]	0.943	0.016
Fres, z-score	0.85 [− 0.70; 1.02]	0.54 [− 0.87; 2.61]	− 0.90 [− 3.79; 2.35]	0.46 [− 1.01; 1.89]	0.18 [− 0.87; 0.96]	0.17 [− 0.84; 1.12]			0.481
R20Hz, kPa/L/s	0.47 [0.31; 0.58]	0.43 [0.28; 0.54]	0.43 [0.29; 0.52]	0.47 [0.39; 0.61]	0.49 [0.39; 0.61]	0.43 [0.33; 0.65]	0.607	0.075
R20Hz, z-score	1.53 [0.84; 2.25]	1.60 [0.70; 2.18]	1.59 [0.32; 2.00]	1.64 [1.16; 2.68]	1.70 [1.04; 2.42]	1.62 [1.31; 2.37]			0.660
R5Hz, kPa/L/s	0.64 [0.38; 0.80]	0.60 [0.37; 0.75]	0.41 [0.35; 0.76]	0.59 [0.45; 0.88]	0.61 [0.46; 0.85]	0.51 [0.42; 1.16]	0.217	0.034
R5Hz, z-score	1.31 [0.51; 2.35]	1.10 [0.20; 2.56]	0.84 [0.15; 1.69]	1.32 [0.54; 2.46]	1.17 [0.54; 1.85]	1.17 [0.83; 3.77]			0.895
R5–20 Hz, kPa/L/s	0.17 [0.06; 0.22]	0.12 [0.05; 0.22]	0.07 [0.02; 0.23]	0.15 [0.07; 0.32]	0.14 [0.06; 0.19]	0.11 [0.07; 0.34]	0.049	0.278
R5–20 Hz, z-score	0.47 [0.04; 1.70]	0.33 [− 0.32; 1.42]	0.25 [− 0.36; 1.12]	0.55 [− 0.42; 1.57]	0.49 [− 0.49; 0.87]	0.62 [0.30; 2.00]			0.509
X5Hz, kPa/L/s	− 0.24 [− 0.34; − 0.20]	− 0.23 [− 0.33; − 0.19]	− 0.16 [− 0.33; − 0.14]	− 0.19 [− 0.31; − 0.15]	− 0.20 [− 0.27; − 0.15]	− 0.16 [− 0.31; − 0.12]	0.604	0.041
X5Hz, z-score	1.59 [0.58; 2.27]	1.48 [0.87; 1.67]	0.83 [0.67; 1.52]	0.88 [0.06; 1.72]	0.57 [0.16; 1.21]	0.76 [0.45; 2.11]			0.065
AX, kPa/L	1.34 [0.73; 2.76]	1.21 [0.68; 2.87]	0.39 [0.35; 2.97]	1.18 [0.50; 2.98]	1.16 [0.58; 2.06]	0.86 [0.41; 3.97]	0.328	0.016
AX, % z-score	0.92 [0.70; 1.91]	1.25 [0.45; 1.73]	0.84 [0.31; 2.02]	0.82 [0.21; 2.75]	0.76 [0.00; 1.28]	0.90 [0.51; 2.63]			0.253
eRIC model
RcentralRS, kPa/L/s	0.49 [0.32; 0.56]	0.44 [0.29; 0.52]	0.42 [0.29; 0.48]	0.49 [0.40; 0.60]	0.50 [0.40; 0.62]	0.41 [0.33; 0.63]	0.600	0.116	0.403
IRS × 100, kPa/L/s2	1.02 [0.90; 1.16]	0.91 [0.88; 1.01]	0.97 [0.90; 1.09]	0.97 [0.76; 1.15]	0.98 [0.75; 1.10]	0.95 [0.80; 1.13]	0.159	0.023	0.567
CpRS × 100, L/kPa	7.83 [5.57; 11.63]	7.15 [5.90; 12.48]	16.14 [5.51; 18.86]	8.80 [4.00; 15.28]	9.44 [7.00; 15.37]	11.05 [4.00; 16.34]	0.416	0.011	0.930
RperipheralRS, kPa/L/s	0.89 [0.68; 1.04]	0.71 [0.50; 0.94]	0.77 [0.62; 5.00]	1.00 [0.77; 1.67]	1.01 [0.66; 1.05]	0.67 [0.51; 1.14]	0.082	0.311	0.403

VD is the anatomical volume of airways; AD denotes Autogenic Drainage

^$ The 7 children with airflow limitation who had a bronchodilator test had z-scores of FEV₁ of − 2.72 [− 3.79; − 2.31] and FVC of − 1.55 [− 1.90; − 1.00] that have to be compared to the “After salbutamol” results

ND denotes not done. Bold P values are those < 0.05

The correlations between VD and height were highly significant (before physiotherapy: R = 0.91; after physiotherapy: R = 0.86, p < 0.0001 for both) justifying the normalisation