Table 3.
Multivariate logistic regressions evaluating covariate associations with cachexia incidence at diagnosis including glucocorticoid and NSAID medication use groups.
| Variable | Odds ratio (95% CI) | P-value |
|---|---|---|
| Age at diagnosis | 1.012 (1.004, 1.020) | 0.0026 |
| Female sex | 0.810 (0.678, 0.968) | 0.0206 |
| Race | ||
| Asian or Pacific Islander | – | <0.0001 |
| Black | 1.602 (1.034, 2.482) | 0.0350 |
| Non-Hispanic White | 0.719 (0.471, 1.098) | 0.1262 |
| Hispanic | 1.508 (0.947, 2.401) | 0.0838 |
| Other/unknown | 1.042 (0.528, 2.06) | 0.9049 |
| Alcohol history | 0.924 (0.777, 1.099) | 0.3719 |
| Tobacco history | 1.363 (1.100, 1.688) | 0.0046 |
| Charlson Comorbidity Index | ||
| 0 | – | 0.0400 |
| 1 | 0.979 (0.797, 1.201) | 0.8362 |
| 2 | 0.848 (0.655, 1.098) | 0.2117 |
| 3+ | 0.690 (0.524, 0.909) | 0.0084 |
| Primary Tumor Site | ||
| Anal | – | <0.0001 |
| Colorectal | 0.762 (0.435, 1.335) | 0.3420 |
| Gastroesophageal | 2.491 (1.400, 4.430) | 0.0019 |
| Hepatobiliary | 0.735 (0.406, 1.332) | 0.3108 |
| Pancreatic | 2.814 (1.547, 5.118) | 0.0007 |
| NSCLC | 0.725 (0.420, 1.252) | 0.2483 |
| Small-cell lung cancer | 0.824 (0.431, 1.575) | 0.5590 |
| Tumor stage | ||
| I | – | <0.0001 |
| II | 1.232 (0.882, 1.719) | 0.2208 |
| III | 2.309 (1.728, 3.086) | <0.0001 |
| IV | 3.290 (2.477, 4.369) | <0.0001 |
| Prior glucocorticoid use | 1.046 (0.778, 1.406) | 0.7665 |
| Prior NSAID use | 0.770 (0.594, 0.998) | 0.0481 |
P values bolded if <0.05.