. 2022 Jun 21;12:97. doi: 10.1186/s13578-022-00833-3

Table 2.

Overview of cellular functions of circRNAs in pancreatic cancer

No	Circ	Host gene	Vitro Functions							Specimen	Expression	Reference
No	Circ	Host gene	Prolife	Cycle	Apopt	Migra	Invas	Angio	Other	Specimen	Expression	Reference
1	ciRS7	CDR1as	+				+			BXPC3/PANC1	Up	30,898,507
2	0000284	HIPK3	+							BXPC3	Up	29,255,366
3	0005273	PTK2	+			+				ASPC1/CFPAC1	Up	33,275,224
4	chr12:7,467,880,474,700,449		+							BXPC3	Up	32,879,441
5	0001649	SHPRH	+		+					BXPC3/PANC1	Down	29,969,694
6	ASH2L	ASH2L	+	+		+	+	+		CAPAN1/ASPC1	Up	31,718,694
7	0001460	NEIL3	+	+		+	+			CFPAC1/MIAPACA2	Up	33,750,389
8	0013912	POLR3C	+	+	+	+	+			ASPC1/PANC1	Up	32,884,344
9	0050102	PGPEP1	+	+	+	+	+			CFPAC1/PANC1	Up	33,289,016
10	0000662	AXIN1	+	+	+	+	+			ASPC1	Down	33,425,718
11	0000677	ABCC1	+		+	+	+			ASPC1/BXPC3	Up	33,413,045
12	0007534	DDX42	+		+	+				PANC1/SW1990	Up	30,382,592
13	0001946	CDR1as	+		+	+	+			ASPC1/PANC1	Up	33,593,338
14	0006215	SLC4A7	+		+	+				PANC1	Up	29,930,719
15	0060055	EIF6	+		+	+	+			HS766T/SW1990	Up	33,469,368
16	0066147	SFMBT1	+		+	+	+			BXPC3/PANC1	Up	32,855,541
17	0071036	INPP4B	+		+		+			ASPC1/PANC1	Up	33,507,122
18	0099999	ZMYM2	+		+		+			CFPAC1/PANC1	Up	30,537,731
19	IARS	IARS							Endothelial permeability	Exo-HUVEC/ASPC1/HS766T/HS766T-L2	Up	30,064,461
20	0036627	PDE8A	+			+	+	+	Scatteration	BXPC3/CAPAN2/Exo-HS766T	Up	29,709,702
21	ADAM9	ADAM9	+			+	+			CAPAN1/MIAPACA2	Up	31,810,373
22	0000069	STIL	+	+	+	+	+			MIAPACA2/SW1990; Exo-HPDE/SW1990	Up	33,324,055
23	0009065	BFAR	+			+	+			BXPC3/PANC1	Up	32,375,768
24	0043278	TADA2A	+			+	+			PANC1/SW1990	Up	33,505,218
25	0075829	CASC15	+			+	+			BXPC3/SW1990	Up	33,184,989
26	chr7:154,954,255,154,998,784		+			+	+			PANC1 + NAPSC/CAPSC	Up	33,042,405
27	LDLRAD3	LDLRAD3	+			+	+			PANC1/SW1990	Up	31,521,692
28	0001013	KIAA1841	+			+	+	+		ASPC1/PANC1	Up	33,563,550
29	0001568	DUSP22	+	+	+		+	+		BXPC3/CAPAN2	Up	32,193,152
30	0000979	TCONS_00003590	+			+	+	+		PANC1	Down	32,878,470
31	0086375	NFIB				+		+		CAPAN2/PANC1	Down	32,366,257
32	circ 03955		+		+				Glycolysis	BXPC3/PANC1	Up	33,864,618
33	0007334	MBOAT2	+		+	+	+		Glutamine metabolism	PANC1/SW1990	Up	33,832,516
34	0000977	NOL10							Inhibition of NK cells under hypoxia	PANC1/NK cell	Induced by hypoxiain	31,402,756
35	0007367	UBAP2							Immune infiltration	GSE69362 and GSE79634	Up	31,584,877
36	0002130	C3								PANC1/SW1990; PDX tumor	Up	32,727,565
37	0092314	RANBP1	+				+		CSC	ASPC1/PACA2	Up	33,842,379
38	0005397	RHOT1	+			+	+			CAPAN2/PANC1	Up	30,444,423
39	0007334	MBOAT2				+				PANC1		31,428,151
40	0030235	RCBTB2	+		+	+	+			PANC1/SW1990	Up	30,591,218
41	0000816	FOXK2	+	+	+	+	+			CFPAC1/PANC1	Up	32,217,695
42	0006988	LDLRAD3								ASPC1/CAPAN2/HPCY5/HPDE6C7/PANC1/SW1990	Up	29,307,994
43	chr14:101,402,109,101,464,448	SNHG23			+				GEM-resistance	PANC1-GEM	Up	29,922,161
44	chr4:5,272,960,352,780,244	DCUN1D4			+				GEM-resistance	PANC1-GEM	Up	29,922,161
45	0000284	HIPK3	+		+	+	+		GEM-resistance	PANC1/SW1990-GEM	Up	32,104,074
46	101672/004077/003251								GEM-resistance	SW1990-GEM	Up	29,781,033
47	101543/002747/000926								GEM-resistance	SW1990-GEM	Down	29,781,033

Prolife: Proliferation; Cycle: Cell cycle; Apopt: Apoptosis; Migra: Migration; Invas: Invasion; Angio: Angiogenesis; CSC: Cancer Stem Cell; GEM: Gemcitabine