Table 4.

Overview of prognostic, diagnostic and clinicopathological significance of circRNAs in pancreatic cancer tissues

No	Circ	Expression	Cut-off	Detect	Variables								AUC	Survival	Prognostic biomarker	Reference
					Size	Differentiation	T	Lymphatic (N)	Distance (M)	TNM	Vessel invasion	Other
1	0001946/0005397	Up		qRT-PCR												27,997,903
2	0006913/0000257/0005785/0041150/0008719	Down		qRT-PCR												27,997,903
3	100433/101717/102049/102051/102619/103076/103390/104084/104270	Up		qRT-PCR												29,620,241
4	000167	Down		qRT-PCR												29,620,241
5	0001946	Up		qRT-PCR												33,593,338
6	0006215	Up		qRT-PCR												29,930,719
7	0066147	Up		qRT-PCR												32,855,541
8	0007334	Up		qRT-PCR												31,428,151
9	0000816	Up		qRT-PCR												32,217,695
10	chr12:74,678,804–74,700,449	Up		qRT-PCR and FISH				+		+						32,879,441
11	ciRS-7	Up		qRT-PCR				+			+					30,898,507
12	0013912	Up		qRT-PCR				+		+						32,884,344
13	0006988	Up		qRT-PCR			+	+		+	+					29,307,994
14	0050102	Up		qRT-PCR						+						33,289,016
15	0000662	Down		qRT-PCR						+						33,425,718
16	0099999			qRT-PCR				+								30,537,731
17	0075829	Up		qRT-PCR	+			+								33,184,989
18	0007334	Up		qRT-PCR						+						33,832,516
19	0000977	Up in high-HIF1A PC tissues		qRT-PCR												31,402,756
20	0071036	Up	MEL	qRT-PCR				+				PET-CT SUVmax value	0.65	OS	+	33,507,122
21	0000677	Up	MEL	qRT-PCR				+		+	+			OS	+	33,413,045
22	0000069	Up		qRT-PCR	+				+				0.8944			33,324,055
23	0,060,055	Up		qRT-PCR						+			0.9093			33,469,368
24	0036627	Up	MEL	qRT-PCR			+	+		+				OS	+	29,709,702
25	0001460	Up	MEL	qRT-PCR							+			OS	+	33,750,389
26	0007534	Up	MEL	qRT-PCR			+	+						OS	+	30,382,592
27	IARS	Up	MEL	qRT-PCR					+	+	+			OS	+	30,064,461
28	0030235	Up		qRT-PCR	+			+						OS	+	30,591,218
29	ASH2L	Up		qRT-PCR				+		+				OS	+	31,718,694
30	0001013	Up	MEL	qRT-PCR		+		+	+	+				OS		33,563,550
31	ADAM9	Up		qRT-PCR				+		+				OS		31,810,373
32	0000284	Up		qRT-PCR								GEM resistance		OS		32,104,074
33	LDLRAD3	Up		qRT-PCR										OS		31,521,692
34	0001568	Up		qRT-PCR and FISH										OS		32,193,152
35	03955	Up		qRT-PCR										OS		33,864,618
36	0009065	Up		qRT-PCR						+				OS/DFS	+	32,375,768
37	0092314	Up	MEL	qRT-PCR		+		+		+				OS/DFS		33,842,379
38	0005273	Up		qRT-PCR				+	+					OS/PFS		33,275,224
39	0001649	Down	MV	qRT-PCR		+	+							OS	+	29,969,694
40	0000979	Down	MEL	qRT-PCR		+		+						OS		32,878,470
41	0086375	Down		qRT-PCR				+		+				OS/DFS	+	32,366,257

MEL: Median Expression Level; MV: Mean Value; GEM: Gemcitabine; AUC: Area Under the Curve; OS: Overall Survival; DFS: Disease-free Survival; PFS: Progression-free survival