Table 5.

Overview of prognostic, diagnostic and clinicopathological significance of circRNAs in pancreatic cancer plasmas

No	Circ	Expression	Cut-off	Detect	Clinical significance	AUC	Sensitivity	Specificity	Survival	Prognostic biomarker	Reference
1	0002130/0000896/0101692/0005882/0001250/0000128	Up		qRT-PCR							31,605,569
2	0103896/0006662/0035432/0094190	Down		qRT-PCR							31,605,569
3	0,001,013	Up		qRT-PCR							33,563,550
4	chr12:74,678,804–74,700,449	Up		qRT-PCR							32,879,441
5	0006988	Up		qRT-PCR	CA19-9 level, Vessel invasion, Lymphatic invasion, Distance metastasis, TNM stage	0.67	0.5738	0.7049			29,307,994
6	0000677	Up		qRT-PCR		0.716	0.6276	0.7429			33,413,045
7	0036627		MEL	qRT-PCR	Duodenal invasion, Vessel invasion, T stage, TNM stage				OS	+	29,709,702
8	IARS	Up		qRT-PCR	Exosomes from patients with or without metastasis						30,064,461
9	chr14:101,402,109–101,464,448/chr4:52,729,603–52,780,244	Up in non-GEM-responsive		qRT-PCR							29,922,161

MEL: Median Expression Level; AUC: Area Under the Curve; OS: Overall Survival