Table 1.
Patient characteristics at enrolment
| General characteristics | Overall (n = 6086) |
% DR | 2011–2021 (n = 1243) |
2000–2010 (n = 4843) |
p value** |
|---|---|---|---|---|---|
| Age (year) | 63 (59–65) | (95.9) | 63 (59–65) | 63 (58–67) | 0.52 |
| Male (n, %) | 3552 (58.3) | (87.1) | 2837 (58.6) | 715 (57.5) | 0.52 |
| SAPS II (points) | 53 (45–59) | (39.5) | 55 (45–60) | 53 (40–57) | 0.34 |
| SOFA (points) | 10 (7–11) | (22.5) | 10 (7–11) | 11 (9–14) | 0.10 |
| APACHE (points) | 20 (19–26) | (22.5) | 24 (19–27) | 19 (12–21) | 0.12 |
| Data regarding respiratory support | (70.9) | ||||
| Totally controlled ventilatory support (n; %) | 2658 (56.6) | 1955 (56.2) | 703 (57.9) | 0.29 | |
| PCV (n; %) | 150 (3.2) | 128 (3.6) | 22 (1.8) | ||
| VCV (n; %) | 2428 (51.7) | 1747 (50.2) | 681 (56.1) | ||
| APRV (n; %) | 80 (1.7) | 80 (2.3) | 0 (0–0) | ||
| Partially controlled ventilatory support (n; %) | 1503 (32.0) | 1161 (33.4) | 342 (28.1) | 0.05 | |
| ACV (n; %) | 1256 (26.7) | 990 (28.4) | 266 (21.9) | ||
| PSV (n; %) | 247 (5.3) | 171 (4.9) | 76 (6.2) | ||
| Spontaneously breathing (n; %) | 530 (10.1) | 362 (10.4) | 168 (13.8) | 0.001 | |
| VT (mL/Kg ideal body weight) | 7 (7–8) | (70.9) | 7 (6–8) | 8 (7–9) | 0.03 |
| Type of patients* | (91.9) | ||||
| Sepsis/septic shock (%) | 3546 (50.6) | 2823 (50.5) | 723 (51.2) | 0.63 | |
| Haemorrhagic/hypovolemic shock (%) | 344 (4.9) | 252 (13.9) | 92 (6.5) | < 0.0001 | |
| Trauma (%) | 120 (1.7) | 101 (1.8) | 19 (1.3) | 0.25 | |
| ARDS/pneumonia (%) | 1741 (24.8) | 1428 (25.5) | 313 (22.2) | 0.009 | |
| Postoperative optimization (%) | 1005 (14.3) | 780 (13.9) | 225 (15.9) | 0.06 | |
| Cardiogenic (%) | 193 (2.7) | 160 (2.8) | 33 (2.3) | 0.31 | |
| Other (%) | 53 (0.7) | 47 (2.8) | 6 (0.5) | 0.12 |
Data presented as median (25th–75th IQR), as appropriate; % DR, percentage of studies reporting the data indicated, SAPS, simplified acute physiology score; SOFA, sequential organ failure assessment; APACHE, Acute Physiologic Assessment and Chronic Health Evaluation; PCV, pressure-controlled ventilation; VCV, volume-controlled ventilation; APRV, Airway pressure release ventilation; ACV, assisted-controlled ventilation; PSV, pressure support ventilation; ARDS, acute respiratory distress syndrome; VT, tidal volume. *The overall number of patients stratified by typology is more significant as compared to the overall number of patients included in the studies because of partial overlapping classification (i.e., sepsis/septic shock and ARDS/pneumonia); **p value refers to the comparison between 2000–2010 versus 2011–2021 subgroups