Table 3.
Haemodynamic parameters before and after fluid challenge administration in responders and non-responders
| Haemodynamic variable | % DR | Pre FC | Post FC | % change pre versus post FC |
p value–pre FC R versus NR |
p value pre FC versus post FC |
|---|---|---|---|---|---|---|
| CI (L/min/m2) | 44.3 | |||||
| R | 2.8 (2.5–3.2) | 3.6 (3.0–4.1) | 29 (23–33) | 0.0003 | < 0.0001 | |
| NR | 3.3 (2.7–3.6) | 3.4 (2.9–3.7) | 5 (0–6) | 0.09 | ||
| SVI (ml/m2) | 22.6 | |||||
| R | 29 (26–33) | 39 (36–42) | 29 (25–38) | 0.0001 | < 0.0001 | |
| NR | 36 (31–41) | 37 (31–42) | 3 (− 1; 7) | 0.05 | ||
| MAP (mmHg) | 73.4 | |||||
| R | 70 (68–74) | 82 (77–85) | 14 (10–18) | 0.005 | < 0.0001 | |
| NR | 74 (70–80) | 78 (75–85) | 6 (4–8) | < 0.0001 | ||
| SAP (mmHg) | 33.9 | |||||
| R | 104 (99–108) | 123 (113–129) | 17 (12–22) | 0.002 | < 0.0001 | |
| NR | 109 (105–118) | 116 (109–123) | 5 (4–8) | < 0.0001 | ||
| PAOP (mmHg) | 14.5 | |||||
| R | 11 (10–12) | 15 (12–16) | 28 (18–45) | 0.05 | < 0.0001 | |
| NR | 13 (10–14) | 16 (13–18) | 28 (15–37) | 0.005 | ||
| CVP (mmHg) | 42.7 | |||||
| R | 9 (7–11) | 11 (10–13) | 30 (19–41) | 0.03 | < 0.0001 | |
| NR | 10 (8–12) | 13 (10–15) | 26 (15–38) | < 0.0001 | ||
| HR (beats/min) | 75.8 | |||||
| R | 98 (88–105) | 94 (86–101) | − 3 (− 4; − 1) | 0.03 | < 0.0001 | |
| NR | 94 (86–101) | 91 (84–98) | − 2 (− 3; − 1) | < 0.0001 | ||
| PPV (%) | 30.6 | |||||
| R | 15 (12–18) | 9 (5–11) | − 42 (− 53; − 29) | < 0.0001 | < 0.0001 | |
| NR | 8 (6–10) | 7 (5–9) | − 15 (− 28; 0) | 0.0002 | ||
| SVV (%) | 14.5 | |||||
| R | 14 (12–17) | 10 (6–12) | − 36 (− 45; − 30) | < 0.0001 | 0.0002 | |
| NR | 11 (8–13) | 9 (6–11) | − 22 (− 33; − 9) | 0.002 |
Data are presented as median (25th–75th interquartile) in responders (R) and non-responders (NR), n = 21; FC, fluid challenge; CI, cardiac index; SVI, stroke volume index; MAP, mean arterial pressure; SAP, systolic pressure variation; HR, heart rate; PPV, pulse pressure variation; SVV, stroke volume variation, CVP, central venous pressure; PAOP, pulmonary artery occluded pressure; %DR, percentage of data reported in the studies