Table 2.
HRs (95% CIs) for incident myocardial infarction and all-cause mortality per trajectory of SUA trajectories
| SUA trajectory group | ||||
|---|---|---|---|---|
| Low-stable | Moderate-stable | High-stable | P for trend | |
| Myocardial infarction | ||||
| Cases, n (%) | 342 (0.78) | 372 (1.08) | 103 (1.48) | <0.0001 |
| Incidence ratea | 1.18 (1.07–1.32) | 1.66 (1.50–1.84) | 2.29 (1.89–2.77) | |
| Model 1 | Reference | 1.41 (1.21–1.63) | 1.94 (1.56–2.42) | <0.0001 |
| Model 2 | Reference | 1.14 (0.98–1.32) | 1.53 (1.22–1.91) | <0.0001 |
| Model 3 | Reference | 1.10 (0.95–1.28) | 1.35 (1.07–1.71) | 0.0146 |
| Sensitivity analysisb | Reference | 1.09 (0.93–1.27) | 1.33 (1.05–1.67) | 0.0264 |
| Sensitivity analysisc | Reference | 1.06 (0.88–1.28) | 1.50 (1.14–1.97) | 0.0158 |
| Sensitivity analysisd | Reference | 1.06 (0.91–1.23) | 1.33 (1.06–1.66) | 0.0317 |
| Sensitivity analysise | Reference | 1.10 (0.94–1.28) | 1.33 (1.05–1.68) | 0.0246 |
| All-cause mortality | ||||
| Cases, n (%) | 2886 (6.54) | 2884 (8.38) | 728 (10.48) | <0.0001 |
| Incidence rate | 9.96 (9.61–10.30) | 12.80 (12.40–13.30) | 16.10 (14.90–17.30) | |
| Model 1 | Reference | 1.29 (1.23–1.36) | 1.63 (1.50–1.76) | <0.0001 |
| Model 2 | Reference | 1.00 (0.95–1.05) | 1.18 (1.09–1.28) | 0.0040 |
| Model 3 | Reference | 1.04 (0.98–1.10) | 1.22 (1.12–1.33) | <0.0001 |
| Sensitivity analysisb | Reference | 1.04 (0.99–1.10) | 1.20 (1.10–1.30) | <0.0001 |
| Sensitivity analysisc | Reference | 1.04 (0.98–1.11) | 1.24 (1.12–1.38) | 0.0003 |
| Sensitivity analysisd | Reference | 1.02 (0.94–1.05) | 1.15 (1.06–1.26) | 0.0022 |
| Sensitivity analysisf | Reference | 1.03 (0.97–1.10) | 1.21 (1.10–1.34) | 0.0010 |
Model 1: unadjusted
Model 2: adjusted for age, gender, and baseline SUA
Model 3: further adjusted for education, income, smoking status, alcohol use, physical activity, history of hypertension, diabetes and dyslipidemia, antihypertensive agents, hypoglycemic agents, lipid-lowering agents, body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, estimated glomerular filtration rate, and high-sensitivity C-reactive protein
Abbreviations: CI Confidence interval, HR Hazard ratio, SUA Serum uric acid
aIncidence rate per 1000 person-years
bSensitivity analysis was adjusted for average body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, estimated glomerular filtration rate, high-sensitivity C-reactive protein, and SUA during the exposure period and other variables at baseline in model 3
cSensitivity analysis excluded incident myocardial infarction or death within the first 2 years of follow-up and adjusted for variables in model 3
dSensitivity analysis was adjusted for metabolic syndrome instead of its components and other variables in model 3
eSensitivity analysis was conducted using Fine-Gray competing risk model considering non-MI deaths as competing risk events and adjusted for variables in model 3
fSensitivity analysis excluded participants with cardiovascular or cerebrovascular disease and adjusted for variables in model 3