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. 2022 Jun 21;13:269. doi: 10.1186/s13287-022-02949-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Declines in EGFR expression restricted wound healing and EGF efficacy in aged epidermis. a Gross view of wounds with different treatments post-wounding. N = 6. *P < 0.05, **P < 0.01 vs. the control group. b 1 mm epidermis samples from the wound margin of 2 M SD rats were analyzed by Western Blot. N = 6. *P < 0.05, **P < 0.01 vs. the control group. c We generated 10 mm full-thickness cutaneous wounds on the backs of 2 M, 17 M and 23 M rats, and animals of each age were randomly divided into control group and EGF-treated group that received a total 200 μL drug (PBS, 10 μg/mL EGF) sprayed evenly on the wound everyday post wounding. N = 6. *P < 0.05 and **P < 0.01 were used to indicate the difference between the control group and the EGF-treated group within the rats of each age at time points. #P < 0.05 and ##P < 0.01 were used to indicate the difference between the control group of 2 M, 17 M and 23 M rats at time-points