| Methods |
As part of her PhD thesis, Halahakoon and colleagues evaluated the effects of poractant, beractant and colfosceril palmitate (Exosurf Neonatal) |
| Participants |
Infants 24 to 32 weeks gestation with RDS requiring assisted ventilation and FiO2 > 0.4 at < 12 hours of age |
| Interventions |
Poractant alfa (n = 17), beractant (n = 10) and colfosceril palmitate (Exosurf neonatal) (n = 12) |
| Outcomes |
Primary outcomes: cerebral function, hypoxanthine levels and antioxidant levels. Also reported on common complications of prematurity and death. |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Not described |
| Allocation concealment (selection bias) |
Low risk |
Sealed envelopes opened at the time of randomization |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
Not reported |
| Blinding of participants and personnel (performance bias)
All outcomes |
Unclear risk |
Not reported |
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
Complete follow‐up: yes |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
No |
