Table 3.
Univariable and multivariable analysis to identify predictors of overall survival of HCC patients after radical resection
| Variable | Univariable | Multivariable | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |||
| Lower | Upper | Lower | Upper | |||||
| Age (years) | 0.993 | 0.974 | 1.012 | 0.449 | ||||
| Sex (male/female) | 0.716 | 0.399 | 1.286 | 0.264 | ||||
| BCLC stage (0/A/B) | 1.484 | 1.009 | 2.182 | 0.045 | ||||
| HBsAg (negative/positive) | 1.546 | 0.775 | 3.084 | 0.216 | ||||
| HBV-DNA (< 5 × 102IU/ml/≧5 × 102IU/ml) | 1.855 | 1.151 | 2.988 | 0.011 | 1.791 | 1.093 | 2.933 | 0.021 |
| Anti-HCV (negative/positive) | 0.455 | 0.063 | 3.284 | 0.435 | ||||
| Tumor diameter (cm) | 1.116 | 1.066 | 1.169 | < 0.001 | 1.073 | 1.018 | 1.131 | 0.009 |
| Tumor number (1/≥2) | 1.415 | 0.913 | 2.193 | 0.121 | ||||
| Tumor envelope (complete/incomplete) | 2.281 | 1.459 | 3.569 | < 0.001 | 2.169 | 1.368 | 3.440 | 0.001 |
| Ascites (negative/positive) | 1.862 | 1.055 | 3.286 | 0.032 | 1.659 | 0.922 | 2.985 | 0.091 |
| AFP (<400 ng/ml/≥400 ng/ml) | 1.237 | 0.824 | 1.857 | 0.305 | ||||
| WBC (*109/L) | 1.006 | 0.909 | 1.112 | 0.913 | ||||
| N% (%) | 1.018 | 0.998 | 1.039 | 0.082 | ||||
| L% (%) | 0.977 | 0.955 | 1.001 | 0.056 | ||||
| HB (g/L) | 0.998 | 0.987 | 1.010 | 0.771 | ||||
| PLT (*109/L) | 1.000 | 0.997 | 1.003 | 0.996 | ||||
| FPG (mmol/L) | 1.017 | 0.915 | 1.130 | 0.756 | ||||
| PT (s) | 1.041 | 0.876 | 1.237 | 0.651 | ||||
| INR | 1.658 | 0.310 | 8.872 | 0.554 | ||||
| TBiL (μmol/L) | 0.989 | 0.959 | 1.021 | 0.505 | ||||
| Alb (g/L) | 0.974 | 0.930 | 1.020 | 0.268 | ||||
| PA (mg/L) | 0.996 | 0.994 | 0.999 | 0.018 | 0.998 | 0.995 | 1.001 | 0.268 |
| ALT (U/L) | 0.997 | 0.989 | 1.004 | 0.396 | ||||
| AST (U/L) | 1.001 | 0.996 | 1.006 | 0.603 | ||||
| GGT (U/L) | 1.002 | 1.001 | 1.003 | 0.001 | 1.002 | 1.000 | 1.003 | 0.024 |
| ALP (U/L) | 1.006 | 1.003 | 1.008 | < 0.001 | 1.004 | 1.001 | 1.008 | 0.026 |
| CK19 (negative/positive) | 1.641 | 1.060 | 2.540 | 0.026 | 1.471 | 0.936 | 2.313 | 0.094 |
| MVI (negative/positive) | 2.132 | 1.409 | 3.225 | < 0.001 | 1.808 | 1.171 | 2.787 | 0.007 |
Abbreviations: AFP alpha fetoprotein, Alb albumin, ALP alkaline phosphatase, ALT alanine aminotransferase, anti-HCV antibodies against hepatitis C virus, AST aspartate aminotransferase, BCLC Barcelona Clinic liver cancer, CK19 cytokeratin 19; FPG fasting plasma glucose, GGT γ-glutamyl transpeptidase, HB hemoglobin, HBsAg hepatitis B surface antigen, INR international normalized ratio, L% lymphocyte percentage, N% neutrophil percentage, MVI microvascular invasion, PA prealbumin, PLT blood platelets, PT prothrombin time, TBiL total bilirubin, WBC white blood cells