Table 5.
Hepatic bio-indices parameters and enzyme activities of rat serum with acute aflatoxicosis and after therapy.
| Parameters | Healthy control (n=8) | AFB1 (n=8) | AFB1+IV BM - MSCs (n=8) | AFB1+IH BM - MSCs (n=8) | AFB1+IV HDCs (n=8) | AFB1+IH HDCs (n=8) | p-value |
|---|---|---|---|---|---|---|---|
| Total protein (g/dL) | 6.14±1.25 | 6.44±1.85 | 6.53±1.44 | 6.48±1.84 | 7.01±1.77 | 6.99±1.08 | 0.1942 |
| ALB (g/dL) | 4.55±1.02 | 3.18*±0.51 | 3.15±0.61 | 3.66±0.88 | 3.46±0.61 | 4.11a±1.14 | 0.0421 |
| Globulin (g/dL) | 3.45±0.11 | 3.98±0.24 | 3.11±0.14 | 3.60±0.42 | 3.15±0.32 | 3.47±0.51 | 0.0933 |
| A\G ratio | 1.2±0.05 | 0.94±0.04 | 1.01±0.10 | 1.01±0.12 | 1.10±0.11 | 1.40±0.20 | 0.5426 |
| Chol (mg/dL) | 89.11±11.52 | 90.34±13.04 | 85.22±6.75 | 75.17±8.55 | 81.05±11.43 | 89.38±12.42 | 0.7114 |
| ALT/GPT (U/L) | 65.90±4.68 | 89.07*±6.52 | 64.11a±8.51 | 61.99a±8.01 | 91.15±9.54 | 69.03a±8.52 | 0.0030 |
| AST/GOT (U/L) | 133.47±12.54 | 164.12*±14.20 | 148.25a±14.25 | 131.38b±12.55 | 178.13±14.85 | 180.24±18.26 | 0.0061 |
| ALP (U/dl) | 124.16±18.58 | 134.55±19.35 | 118.62±20.84 | 124.85±21.77 | 133.01±18.25 | 130.84±20.74 | 0.4430 |
| TG (mg/dL) | 31.06±3.55 | 34.15±4.51 | 33.84±2.40 | 31.42±3.42 | 30.45±5.21 | 32.14±4.20 | 0.3216 |
| NO (umol/L) | 16.05±3.25 | 25.48**±2.09 | 23.84±1.52 | 14.65b±2.87 | 12.88±3.10 | 11.65b±2.84 | 0.0241 |
| MDA (nmol/mL) | 0.489±0.021 | 0.981**±0.01 | 0.882±0.01 | 0.771±0.01 | 0.731±0.06 | 0.431b±0.031 | 0.0077 |
In the same row,
*
and
**
are significantly different than control at P<0.05 and P<0.01 respectively and
a
and
b
are significantly different than AFB1 at P<0.05 and P<0.01, respectively. AFB1=Aflatoxin B1, IV=Intravenous, IH=Intrahepatic, BM-MSCs=Bone marrow mesenchymal stem cells, HDCs=Hepatogenic differentiated cells, ALB=Albumin, A/G=Albumin/globulin, Chol=Cholesterol, ALT=Alanine aminotransferase, AST=Aspartate aminotransferase, ALP=Alkaline phosphatase, TG=Triglyceride, NO=Nitric oxide, MDA=Malondialdehyde