Table 7.
Antioxidant enzyme activities and MDA of hepatic tissues of rat with acute aflatoxicosis and after therapy.
| Parameters | Healthy control (n=8) | AFB1 (n=8) | AFB1+IV BM-MSCs (n=8) | AFB1+IH BM-MSCs (n=8) | AFB1+IV HDCs (n=8) | AFB1+IH HDCs (n=8) | p-value |
|---|---|---|---|---|---|---|---|
| CAT (nmol/min/g tissue) | 34.60±4.11 | 21.44**±2.71 | 31.95a±2.15 | 23.26±2.06 | 26.19±2.28 | 28.12±3.08 | 0.0113 |
| SOD (U/g tissue) | 8.11±1.17 | 5.19*±1.06 | 7.14a±0.35 | 5.90±1.23 | 5.06±1.97 | 8.22a±0.97 | 0.0120 |
| GSH (mM/g tissue) | 7.47±1.51 | 4.95*±0.82 | 6.66±1.30 | 4.57±0.87 | 5.52±0.72 | 7.01a±1.04 | 0.0141 |
| GSH-Px (U/g tissue) | 65.42±5.39 | 45.22*±3.62 | 60.22a±4.81 | 48.16±3.25 | 51.63±5.63 | 58.31a±4.17 | 0.0139 |
| MDA (nmol/g tissue) | 33.85±3.11 | 35.74±2.15 | 31.06±2.05 | 31.83±1.89 | 32.16±3.77 | 32.22±2.16 | 0.4620 |
In the same row,
*
and
**
are significantly different than control at P<0.05 and P<0.01 respectively and
a
is significantly different than AFB1 at P<0.05. AFB1=Aflatoxin B1, IV=Intravenous, IH=Intrahepatic, BM-MSCs=Bone marrow mesenchymal stem cells, HDCs=Hepatogenic differentiated cells, CAT=Catalase, SOD=Superoxide dismutase, GSH=Reduced glutathione, GSH-Px=Glutathione peroxidase, MDA=Malondialdehyde